computer controlled stimulator digitimer ds4 Search Results


ds4  (AutoMate Scientific Inc)
95
AutoMate Scientific Inc ds4
Ds4, supplied by AutoMate Scientific Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/DS4/custom%40ds4%4010%2E64898%2F2026%2E04%2E10%2E717712
Average 95 stars, based on 1 article reviews
ds4 - by Bioz Stars, 2026-09
95/100 stars
  Buy from Supplier
biphasic current stimulator  (Digitimer North America LLC)
95
Digitimer North America LLC biphasic current stimulator
Biphasic Current Stimulator, supplied by Digitimer North America LLC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/DS4/10__1523_slash_jneurosci__1417___23__2023-86-12-17
Average 95 stars, based on 1 article reviews
biphasic current stimulator - by Bioz Stars, 2026-09
95/100 stars
  Buy from Supplier
ds4 bi-phasic stimulus isolator  (Digitimer Ltd)
90
Digitimer Ltd ds4 bi-phasic stimulus isolator
Ds4 Bi Phasic Stimulus Isolator, supplied by Digitimer Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/ds4+stimulator/us11318278-754-17-16
Average 90 stars, based on 1 article reviews
ds4 bi-phasic stimulus isolator - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
arbitrary function generator tektronix afg1062  (Tektronix inc)
90
Tektronix inc arbitrary function generator tektronix afg1062
Arbitrary Function Generator Tektronix Afg1062, supplied by Tektronix inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/function+generator+afg3022c/pm31827103-242-8-10
Average 90 stars, based on 1 article reviews
arbitrary function generator tektronix afg1062 - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
function generator  (Keysight Technologies)
86
Keysight Technologies function generator
Function Generator, supplied by Keysight Technologies, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/generator+waveform/pmc12956711-69-19-22
Average 86 stars, based on 1 article reviews
function generator - by Bioz Stars, 2026-09
86/100 stars
  Buy from Supplier
twisted bipolar stimulating electrode  (PlasticsOne inc)
90
PlasticsOne inc twisted bipolar stimulating electrode
Twisted Bipolar Stimulating Electrode, supplied by PlasticsOne inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/bipolar+stimulating+electrode/bio_rxiv__2020__10__29__359265-254-1-5
Average 90 stars, based on 1 article reviews
twisted bipolar stimulating electrode - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
twisted bipolar stimulating electrode plastics one  (PlasticsOne inc)
90
PlasticsOne inc twisted bipolar stimulating electrode plastics one
Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical <t>stimulating</t> electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).
Twisted Bipolar Stimulating Electrode Plastics One, supplied by PlasticsOne inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/twisted+bipolar+stimulating+electrode+plastics+one/pmc08494762-334-1-5
Average 90 stars, based on 1 article reviews
twisted bipolar stimulating electrode plastics one - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
ds-5 stimulator  (Digitimer Ltd)
90
Digitimer Ltd ds-5 stimulator
Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical <t>stimulating</t> electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).
Ds 5 Stimulator, supplied by Digitimer Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/ds2+isolated+stimulator/bio_rxiv__2023__09__05__556444-130-11-10
Average 90 stars, based on 1 article reviews
ds-5 stimulator - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
low toxicity silicone adhesive  (World Precision Instruments)
96
World Precision Instruments low toxicity silicone adhesive
Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical <t>stimulating</t> electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).
Low Toxicity Silicone Adhesive, supplied by World Precision Instruments, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+controlled+stimulator+digitimer+ds4/Low+Toxicity+Silicone+Adhesive/custom%40kwik-sil%4010%2E1101%2F2023%2E09%2E05%2E556444
Average 96 stars, based on 1 article reviews
low toxicity silicone adhesive - by Bioz Stars, 2026-09
96/100 stars
  Buy from Supplier

Image Search Results


Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical stimulating electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).

Journal: Scientific Reports

Article Title: Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release

doi: 10.1038/s41598-021-99350-5

Figure Lengend Snippet: Characterizing optogenetic patch stimulation on striatal dopamine release. ( a ) Experimental design. Sepw1 NP67 mice were injected with AAV5 driving Cre-dependent expression of ChR2-eYFP. Fast-scan cyclic voltammetry was used to monitor real-time changes in dopamine levels in striatum. An electrical stimulating electrode was placed in the pedunculopontine nucleus (PPTg) to drive increases in dopamine in the dorsal striatum. A fiber optic was placed above patch terminals in the substantia nigra pars compacta (SNc). Electrical or optogenetic or both stimulation types were randomly selected and delivered a minimum of three times each (see Methods). ( b ) (left) Representative recording of electrical stimulation of PPTg. Here, a line shows recorded current relative to stimulation delivery (straight line below current trace) above a pseudo-color plot. The color plot shows current collected (in color) at each waveform scan (y-axis) and across time (x-axis). INSET: a “cyclic voltammogram” collected at the vertical white dotted line on the pseudo-color plot suggesting that dopamine is the predominant analyte being monitored. (right) Same as left, but optogenetic stimulation of patch terminals occurs simultaneously with PPTg electrical stimulation. ( c ) Average responses across replicates for each of the three stimulation types. PPTg stimulation only denoted as E Stim, optogenetic stimulation of patch terminals as Opto. ( d ) Maximum recorded current during stimulation normalized to electrical PPTg stimulation. ( e ) Average cyclic voltammogram across replicates for each stimulation type. * p < 0.05; ** p < 0.01; *** p < 0.001; error bars, SEM. ( a ) drawn in Illustrator CC 2019 (Adobe).

Article Snippet: A twisted bipolar stimulating electrode (Plastics One, Roanoke, VA, USA) connected to a DS4 Biphasic Constant Current Stimulus Isolator (Digitimer) was lowered in 0.1-mm increments starting at − 1.5 DV into PPTg until robust dopamine increases were detected in the dorsal striatum.

Techniques: Injection, Expressing